Tofacitinib Intermediate (2R, 3R) -2,3-bis [(4-methylbenzoyl) oxy] succinic acid ndi (3R, 4R) - N, 4-dimethyl-1- (phenylmethyl) -3-piperidine amine CAS No. 477600 -71-8

Mitundu yathu ya tofacitinib ndi yofunika kwambiri popanga tofacitinib, mankhwala odziwika bwino omwe amagwiritsidwa ntchito pochiza mitundu ina ya nyamakazi.Izi zapakatikati zimagwira ntchito yofunika kwambiri popanga tofacitinib, zomwe zimathandizira kuti zikhale zogwira mtima komanso zabwino.Kudzera (2R, 3R) -2,3-bis[(4-methylbenzoyl)oxy]succinic acid ndi (3R,4R)-N,4-dimethyl-1-(phenylmethyl)- Kuphatikiza kolondola kwa 3-piperidinamines, athu mankhwala amaonetsetsa kaphatikizidwe wa tofacitinib wapamwamba kwambiri womwe umakwaniritsa ndikupitilira miyezo yamakampani.

Mapangidwe a maselo ndi kulemera kwa tofacitinib wapakatikati amawonetsa chiyero chake ndi mphamvu zake, ndikupangitsa kuti ikhale gawo lodalirika pakupanga mankhwala.Ndi zosakaniza zake zoyezera mosamala, zapakatikati izi zimatsimikizira kusasinthika ndi mphamvu ya chinthu chomaliza, tofacitinib.Mamolekyu ake amathandizanso kuti tofacitinib ikhale yokhazikika komanso yathanzi, kuwonetsetsa kuti imakhala yothandiza komanso yodalirika pakapita nthawi.