Sankhani Ife
JDK ili ndi malo opangira kalasi yoyamba ndi zida zowongolera Ubwino, zomwe zimatsimikizira kukhazikika kwapakati pa API.Gulu la akatswiri limatsimikizira R&D za malonda.Mosiyana ndi zonsezi, tikufunafuna CMO & CDMO pamsika wapakhomo ndi wapadziko lonse lapansi.
Mafotokozedwe Akatundu
Pachimake chake, 17-amino-10-oxy-3,6,12,15-tetraoxa-9-azaheptadecanoic acid ndi mankhwala ovuta omwe ali ndi mphamvu zambiri m'njira zosiyanasiyana.Mapangidwe ake a mamolekyu ndi kuphatikiza kwapadera kwa zinthu kumapangitsa kuti ikhale yofunika kwambiri pakupanga mankhwala, biochemistry ndi zoyeserera zokhudzana ndi sayansi.
Chimodzi mwazinthu zazikulu za mankhwalawa ndi kusinthasintha kwake.17-Amino-10-oxy-3,6,12,15-tetraoxa-9-azaheptadecanoic acid angagwiritsidwe ntchito ngati chomanga mu synthesis zosiyanasiyana bioactive mamolekyu, monga peptides ndi mapuloteni.Magulu ake ogwira ntchito ndi ma amino acid amatsatizana amathandiza kusintha koyenera komanso kolondola, kuonetsetsa kuti ali ndi ulamuliro wapamwamba komanso wapadera pakupanga mankhwala.
Ofufuza ndi asayansi pazamankhwala ndi kupeza mankhwala adzapindula kwambiri pophatikiza mankhwalawa muzofufuza zawo.Zomwe zitha kugwiritsidwa ntchito zimachokera ku machitidwe operekera mankhwala opangira mankhwala mpaka kupanga zida zatsopano zochizira.Pogwiritsa ntchito mawonekedwe apadera a 17-amino-10-oxy-3,6,12,15-tetraoxa-9-azaheptadecanoic acid, makampani opanga mankhwala amatha kupanga zatsopano ndikupanga chithandizo chambiri cha matenda osiyanasiyana.
Kuonjezera apo, kulimba kwa mankhwalawa kumatsimikizira kukhazikika ndi kudalirika pansi pa zochitika zosiyanasiyana zoyesera.Kulemera kwake kwa mamolekyu ndi mapangidwe ake adapangidwa mosamala kuti apereke kusungunuka koyenera, kulola kusakanikirana kosavuta mu ndondomeko zoyesera.Kuphatikiza apo, chiyero ndi kusasinthika kwazinthu zimatsimikizira zotsatira zomwe zitha kubwerezedwanso, kupangitsa kuti ikhale chida chofunikira kwambiri pazotsatira zodalirika za kafukufuku.
Pankhani yachitetezo, timachita chilichonse kuti tiwonetsetse kuti 17-amino-10-oxy-3,6,12,15-tetraoxa-9-azaheptadecanoic acid ikukwaniritsa miyezo yapamwamba kwambiri.Njira zowongolera zaubwino zimatengedwa nthawi yonse yopangira kuti zitsimikizire kusakhalapo kwa zonyansa zilizonse kapena zonyansa.
![Tofacitinib Intermediate (2R, 3R) -2,3-bis [(4-methylbenzoyl) oxy] succinic acid ndi (3R, 4R) - N, 4-dimethyl-1- (phenylmethyl) -3-piperidine amine CAS No. 477600 -71-8](http://cdn.globalso.com/jdkhc/2R-3R-23-bis-4-methylbenzoyl-oxy-succinic-acid-and-3R-4R-N-4-dimethyl-1-phenylmethyl-3-piperidine-amine.jpg)
